Ovarian epithelial inclusions cysts in chronically superovulated cd1 and smad2 dominant negative mice Short title: Ovulation and ovarian epithelial cysts
نویسندگان
چکیده
JOANNA E. BURDETTE, RACHEL M. OLIVER, VICTORIA ULYANOV, SIGNE M. KILEN, KELLY E. MAYO, AND TERESA K. WOODRUFF Institute for Women’s Health Research (J.E.B., V.U., T.K.W.) Feinberg School of Medicine, Northwestern University, Chicago, IL 60611; Robert H. Lurie Comprehensive Cancer Center of Northwestern University (T.K.W.), Chicago, IL 60611; Department of Biochemistry, Molecular Biology and Cell Biology (K.E.M.), Northwestern University, Evanston, IL 60208; and Center for Reproductive Science (S.M.K., K.E.M., T.K.W.), Northwestern University, Evanston, IL 60208.
منابع مشابه
Ovarian epithelial inclusion cysts in chronically superovulated CD1 and Smad2 dominant-negative mice.
Chronic ovulation as a contributing factor for the development of epithelial ovarian cancer in women has long been an outstanding hypothesis. To test the incessant ovulation hypothesis, mice were superovulated using weekly ip injections of pregnant mare serum gonadotropin (5 IU/animal), followed 48 h later by human chorionic gonadotropin (5 IU/animal). Wild-type CD1 mice were used along with CD...
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Epithelial ovarian cancer is the most lethal gynecological malignancy among US women. The etiology of this disease, although poorly understood, may involve the ovarian surface epithelium or the epithelium of the fallopian tube fimbriae as the progenitor cell. Disruptions in the transforming growth factor beta (TGFβ) pathway and p53 are frequently found in chemotherapy-resistant serous ovarian t...
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BACKGROUND Female CD-1/Swiss Webster mice subjected to incessant ovulation for 8 months and 12-month breeder mice both developed ovarian inclusion cysts similar to serous cystadenomas. The majority of cysts appeared to be dilated rete ovarii tubules, but high ovulation number resulted in more cortical inclusion cysts. We hypothesized that comparison of inclusion cyst pathology in animals of the...
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Ovarian cancer is the most lethal gynecological malignancy affecting American women. Current hypotheses concerning the etiology of ovarian cancer propose that a reduction in the lifetime number of ovulations decreases ovarian cancer risk. Advanced serous carcinoma shares several biomarkers with fallopian tube epithelial cells, suggesting that some forms of ovarian carcinoma may originate in the...
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